The Impact of Ovarian Ageing on Women's Health

Menopause marks a significant transition in a woman's life, often associated with the cessation of fertility and the onset of various health challenges. The decline in estrogen levels during menopause can lead to severe health issues such as increased heart disease risk, obesity, and osteoporosis. However, the underlying mechanisms of these changes, particularly at the cellular and genetic levels, remain poorly understood due to the historical neglect of women's reproductive health research.

In a significant move to bridge this knowledge gap, the NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE) has partnered with Temasek Life Sciences Laboratory (TLL) to form a dedicated research network. This collaboration was officially cemented with a memorandum of understanding signed in February 2024, as reported by The Straits Times.

The Role of ACRLE and TLL in Advancing Women's Health

The joint initiative between ACRLE and TLL aims to delve deeper into the reasons behind ovarian ageing and its variable rates among women. "While ovaries are one of the first organs to age in a woman, it’s not known why and how fast," explained Dr. Huang Zhongwei, deputy director of ACRLE, during a conference at NUHS Tower Block. The research focuses on understanding how factors like chemotherapy, radiotherapy, smoking, and family history contribute to early menopause and altered reproductive lifespans.

Dr. Huang emphasized the importance of this research for women's overall well-being: "One of the key things that we are trying to do at ACRLE is to determine the true ovarian life and health span of women. With this knowledge, we will be able to help every woman maximize their reproductive window and, more importantly, it will be a huge step towards progressing our quest in advancing women’s health and well-being."

The Impact of Research on Future Healthcare

The insights gained from this research are expected to not only enhance the reproductive health of women but also improve their general health and longevity. By understanding the specific needs and risks associated with ovarian ageing, healthcare providers can offer more targeted and effective treatments and preventive measures.

Moreover, this research initiative encourages young Singaporeans to engage actively in developing their understanding and involvement in reproductive health issues, fostering a more informed future generation that can continue to push the boundaries of what is known about women's health.